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Zep is more than just another cleaning company. We are a passionate group who have been perfecting cleaning formulas for homes, businesses, and automobiles for over 85 years with one goal in mind: Making safe and efficacious products that do the job right the first time. Our products give you the efficacy of a deep clean without all the extra work.
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Zep products are all formulated in the U.S. with a dedicated R&D team who knows how to clean everything, from a small stain on a carpet to some of the toughest messes on Earth. And, because we have a professional heritage, our products surpass all standards for safety.
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16 oz. concentrate
Up to 40 treatments
For slow-running drains and preventative maintenance
Not for use with inorganic build-up or hair-clogged drains
Safe for all pluming and septic tanks
9 reviews for Zep Drain Defense Enzymatic Drain Cleaner Powder – 18 Ounces – ZDC16 – Safe for Pipes and Septic Systems, Pack of 1, white
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$12.99

Herbert Sherbert –
Works well!
I love this stuff! I’ve used this for my bathroom shower and sink drains since I had to start being responsible for all the hair that was washing down the drains and it’s been amazing at clearing them out and keeping them flowing. If you are not interested in snaking a drain, this is a great addition to your cleaning routine – I’ve started using it at the beginning of each month for maintenance and I’m happy with the results!
Albert Bickford –
Good price for a (hopefully) useful product
Seems to be a reasonable price for this type of product. I prefer a liquid product, but this power is adequate and easy to use. Each bottle comes with a measuring cup, although sometimes the cup is buried deeply in the bottle rather than right on top, so it’s good to keep the cup from one bottle to be available for the next.I can’t speak to its effectiveness–that’s hard to measure. I did have one drain plug up despite using the product regularly, but it may have just gotten overwhelmed with too much hair going down the drain. Regular drain cleaner cleared it. Still, I keep using it in other drains in the belief (and hope) that it is actually effective in keeping organic residue from building up in pipes.
SoGal –
It’s a job to eliminate drain flies.
I’m writing this review in order to maybe help someone else that has a drain fly problem. I first saw 1-2 drain flies on my tile shower wall. I first started making my own baking soda/salt/vinegar solution and pouring down the drains. I did A LOT of cleaning of the sink and shower pipes. And, I unscrewed and cleaned out the U-pipes under the sinks. I was still seeing a few flies in the bathroom. Secondly, I tried In Vade Bio Drain cleaner (thick gel) from Amazon. Thirdly, I tried ZEP Liquid Heat Gel Industrial Drain Opener (thick gel) from Wal-Mart. Fourthly, I used Zep Drain Defense Pipe Build-Up Remover Power. This one is the best value because you mix only a small scoop with a pint of water. (I do deduct one star because of the packaging. The canister came in a brown flat paper bag like envelope. When I opened the envelope up, powder had spilled out in the bag. When I got that mess cleaned up, I discovered that the scoop was at the bottom of the canister. Other reviewers have also written this. If the canister had a thin plastic seal on the top, it wouldn’t spill out during shipping even if the screw-on cap came off. That’s just a suggestion for the company.) This product says – “Made in the USA”. I think the two (2) Zep products were good ones. After thorough investigation of the tiled shower, which I had stopped using while fly killing, I found dead drain fly larvae around the cracked grout where the grout flooring meets the tile wall of the shower. The flies were breeding in the shower pan. I have had a fan running in the shower 4 days now. I haven’t seen any drain flies in 2 days now. I ordered Tekko Trio Foam from Amazon, and that came in today. I’ve now sprayed that in the crack line of the grout all the way around the shower. During this whole 10 day process, I’ve kept the drain openings covered when not in use.UPDATE: Flies were still not completely eliminated after using multiple products, so I hired a carpenter to tear out the whole shower floor & about 4 inches up the shower wall and start from scratch to replace the shower floor. Whenever the carpenter tore out the tile on the lower 4 inches of the shower bench, 8-9 flies swarmed out. He said it looked like the drain flies had made a little cave under the shower bench. It has been a long process tearing out the shower floor and replacing it. My advice to anyone with drain flies in a tile shower is to keep going further to find the source of the moisture and fix it. Then, you will have no more flies.
S. Huk –
This product does seem to work
I noticed a bit of drain slowness in the kitchen sink. It was backing up into the disposal before finally draining out. That appears to be resolved with 3 uses of the drain cleaner over a period of 3 days.
Amazon Customer –
NO TITLE
THESE WORK TO CLEAN YOUR DRAIN BUT I STILL HAD FLIES AFTER USING IT.
Kindle Customer –
Works but smells terrible.
I had a drain fly problem and unsuccessfully tried some suggestions online for cleaning and unclogging the pipes. I eventually read that an enzyme cleaner might be the best and safest solution to tackle the issue. I bought this product and used it for three nights in a row, leaving it in the kitchen drains overnight, covering the drains, and then rinsing them with hot water the next day. I also used it to clean the garbage disposal as instructed.I believe the drain fly problem is solved for now with the help of this product, deep cleaning my kitchen and using some other methods. The problem is my garbage disposal now smells like rotten sawdust from this powder. I have tried just about everything to clean and sanitize the disposal to remove the smell but it won’t go away. The smell wasn’t there before I used this product. I don’t know what to do.
Danny Fletcher –
It works and works well for old plumbing, especially
I live in apartments that are over 50 years old that has all kinds of buildup in the drains. One treatment in each drain in my house cleared my pipes till they’re running like new. A warning from the plumber that told me about this product. Do one train about every three days if you do all of them in your house at once, it will clear out so much junk that it will plug up your main drain you have to do it a little at a time. I highly recommend this product
A Y –
No
Had to call poison control because it spilled all over my table where my toddler eats. There is no seal. Poor quality control
Adam H –
No amount of cleaners or bleach could get rid of the smell coming from our bathroom drain. Couple doses of this stuff and it’s good as new. Highly recommended!